], I'm going to go out into the streets and offer addicted women money to use birth control. Like have you ever had one of those moments where you suddenly are your dad and it catches you off guard? KARIN BORGKVIST LJUNG: Cancer. The results make it probable that our descendants will learn more quickly what we know well, will execute more easily what we have accomplished with great effort, will be able to withstand what injured us almost to the point of death. Twitter: @wnycradiolab Language: English Contact: WNYC Radio 160 Varick St. New York, NY 10013 (646) 829-4000 Website: http://www.wnyc.org/shows/radiolab/ Email: radiolab@wnyc.org Episodes Golden Goose 2/17/2023 More I'm in public health. I mean like, with the licking, is it a teaching thing where, you know, the babies become good mothers because FRANCES CHAMPAGNE: They've seen it and they've repeated the experience. Destiny says before she was born, her mom had four other girls. [ARCHIVAL Clip, News: Who, together, pledged more than $150,000 to her program.]. JAD: Stretching got into the baby. CARL ZIMMER: mouse or rat? SAM KEAN: Because it would reflect badly on the Soviet state. ROBERT: But the story he told us begins around 25 years ago. You know, you've got all these chemicals around. Were there any consequences? JAD: Started with the tongue. CARL ZIMMER: He hit the lecture circuit and he hit it big. We neuter them.". Kalia came too. And the incredible thing is, those marks stick around. More of this particular protein. Professional authors can write an essay in 3 hours, if there is a certain volume, but it must be borne in mind that with such a service the price will be the highest. It was this struggle for a few years. We have experts even in very specific fields of study, so you will definitely find a writer who can manage your order. The sneaky idea here is that the blacksmiths, the giraffes, they made it happen. Who are they? And in one day, we can imagine, he gets curious. He thought it worked with humans, too. This is nice and quiet. Move on to the next cage, yes, no? KARIN BORGKVIST LJUNG: Yes, he was retarded. Are you nine? And she told Barbara, "There's something you need to know about this baby.". I know! One time, and I'm on flighter. [laughs] We now know that thats not the case. Just until they hatch and then 'til they go off. A given episode might whirl you through science, legal history, and into the home of. fact checked by Jamie Frater. [chuckles]. But I take it that we have more control over our destinies and our kids' destinies than we would've thought. JAD: Hey, wait. They willed the neck to get longer, the muscles to get bigger. [ARCHIVAL CLIP, toddler: Theres the moon.]. That's how I've always looked at it. And, I mean, I have straight A's and I'm making it work. So thats the reason, of course, that we work with rats because we can get inside the brain. JAD: So its like grandpa's struggle is jumping forward and giving me a leg up? Because here's the thing, the churches up in verkalix kept incredibly detailed records. The team that creates each episode, including hosts Jad Abumrad and Robert Krulwich, are master storytellers. They wanted to see basically the effects of starvation on multiple generations. PAT: The way she saw it, the state, the federal government, somebody BARBARA HARRIS: Should say, "You're not doing this. We spay them. Serotonin gets into the brain cells, and according to Michael unleashes A whole series of molecular events inside the cell. BARBARA HARRIS: Yeah, the social worker called and told me the mother had given birth. It's just a mind crushing tedium. So by now it's 1994, and Barbara is thinking You know? You don't think that they should have their children back?]. [laughs] Can you say, "Never, ever?" Please welcome Barbara.]. BARBARA HARRIS: And I knew that the only way I was going to get a daughter was if I went and became a foster parent and asked for one. PAT: As Barbara made the rounds on the daytime talk shows, the reaction was split right down the middle. Since birth. Okay. SECTION I - Story 1 (Lamark, Krammerer & the Midwife Toads) 1. ROBERT: And there were from the beginning. The right hand had been cut off for microscopic slides. The fact that you're motivated by a really beautiful, important value, that we want healthy kids, doesn't mean the mechanism you're using is going to end up helping those kids. Because the Soviets, they believe in Karl Marx's idea that human beings were an improvable species, that if you can change the conditions around people, you change the people. RADIOLAB Podcast "Inheritance" Homework Assignment Name: Rohan Desai PSUID: 9 6241 8529 Listen to the first three stories of the "Inheritance" Radiolab Podcast (Control + click on link to access podcast. You are not God. Yes, no, okay, move on to the next cage, yes, no? JAD: They suddenly had to get by on a tiny fraction of the food that they were used to. Yeah. It might be a mixture. But luckily for the Vivarium and for our story, they had a guy. He works at the Karolinska Institute in Sweden where he studies population data. Oh my goodness. So, the thought is, when those little boys in verkalix were really, really hungry, their hunger started a chemical process that reached all the way down to the DNA inside the boy's sperm. PAT: It would be wrong to assume the women Barbara talks about on TV [ARCHIVAL CLIP, BARBARA HARRIS: These women don't just have one and two babies. Michael was in school and he got interested in a very, very basic question about how things get passed down? Sincerely, Jennifer.". Then she goes, "Oh wait, I didn't give birth to you. JAD: So I guess you could say to yourself, "Seven out of eight of these kids did all right?". LULU: In a very real way, we've been thinking a lot about inheritance. It's writer, Sam Kean again, and here's, he says, what you need to know about the midwife toad. FRANCES CHAMPAGNE: I think that's where Lamarck's ideas can be woven in and make some sense. SAM KEAN: And he would basically turn the heat way, way up in these aquariums until they had to go underwater. [WILL: Hi, this is Will, calling from Northumberland, England. More what kind of stuff? I should add too. But here's what I did not know about DNA. And in1923, he actually comes to England. ROBERT: Which, when you think about it, it has a very Lamarckian flavor. I mean, were not gonna do that ourselves. ROBERT: You wonder, where did that come from? So then over the next 70 some odd years, Lamarck basically became the poster boy for, like, the big dumb idea, the idea that you want to believe in but that you know isn't true. Nice, cool water. I don't think that puts me in the same category as Hitler. It goes back to the 1800s. I'm going to graduate with honors and one day I'm going to be able to tell her, "Look, I did this. PAT: Barbara tried to get a law passed requiring just that. Radiolab is on YouTube! But wouldnt it be nice if thats how it worked? She filled out the forms went BARBARA HARRIS: Through all the training that we had to do and first aid, fingerprinted and had a background check done. To build these terrariums and aquariums and stock them with animals. He's not just talking about toads anymore, he's gone way beyond toads. DESTINY HARRIS: As you can see, I like to talk. PAT: Destiny says one day, she and her mom were in the car, and her mom said DESTINY HARRIS: She said, "I don't know, you know, maybe they'll grow bigger? All the babies I had seen and all the people that have called me to tell me about their babies that were damaged. SAM KEAN: I guess the way I would look at it is that you can change your environment a lot more easily than you can change your genes. One parent stretching isnt going to do anything, see thats the bummer of Darwinian evolution. They have six, seven, eight, ten, fourteen.]. PAT: Just a little. I mean, the idea that they could be constrained by their DNA, that maybe one of us gave them a bit of DNA thats gonna hold them back? JAD: Now, according to Carl, your genes are still fixed. You can't change your DNA. As a parent, you are a tiny blip in a very, very, long story. PAT: Could you just tell us what you are doing now? Like, I mean, as far as positives can go, I think I hit the jackpot. CARL ZIMMER: They'd spend more time in the water. ROBERT: And youre saying that part of the DNA is covered up? But if you've got a mom who licks you. As he's doing his rounds, he stops by the midwife toad terrarium, he looks down at that little male toad with grapes stuck to his legs and he wonders, "How adaptable is that little guy?" Part 2 of our collaboration with Radiolab. And um PAT: Doctors would later explain to Barbara that Destiny's mom had been addicted to drugs while she was pregnant. So some scientists began to ask Kammerer if they could look at his toads. That's what good rat mothers do, they lick their babies a lot. He extended this idea to people. But what exactly. JAD: The sneaky idea here is that the blacksmiths, the giraffes, they made it happen. I'm trying to remember. Who, together, pledged more than $150,000 to her program.]. So for Isaiah, being born was like just being cut off. Radiolab - Transcripts Subscribe 187 episodes Radiolab is on a curiosity bender. DESTINY HARRIS: Our staff includes Alan Horn, Soren Wheeler, Pat Walters DESTINY HARRIS: With help from Matt Kielty, Chris [unintelligible 01:04:17], PAT'S DAD: And Kenny [unintelligible 01:04:18], PAT: Special thanks to Martin [unintelligible 01:04:21]. Radiolab is a radio program produced by WNYC, a public radio station in New York City, and broadcast on public radio stations in the United States. Peanut butter, there we go. CARL ZIMMER: You know, the fact is that taking care of animals, trying to keep them alive in a building is not an easy thing, especially if it's 1903. SAM KEAN: This is what's called the slow growth period. And he makes a very careful study of this hand. When Kammerer published his results initially, a bunch of scientists immediately began to say "Wait a minute, hold on here, it would be nice if life was like that but life isn't like that. PEJK MALINOVSKI: Here we have how much they harvested. It would be wrong to think that they represent all women who use drugs while they're pregnant. JAD: But were gonna play you stories where JAD: This is Radiolab. His famous example was giraffes. At the Vivarium, as the name suggests, they have live animals. JAD: I think all parents do this, is that you slip into this Lamarckian delusion that JAD: What you do with your kids can somehow rewrite all of that. And the incredible thing is, those marks stick around. Or is it? I'm not saying that these women are dogs but they're not acting any more responsible than a dog in heat. Is that too old?" JAD: His big idea, as you might know, is that what a person does in their lifetime could be directly passed to their kids. _. Radiolab is on YouTube! He was really one of the first grand theorists in biology. She and I snuck away from the children into her office. She was totally an oops kid. That's the headline for his talk, and then CARL ZIMMER: Right below the headlines says, "Scientist's great discovery which may change us all.". ", And I called my husband again at work and said, "They want to know if we want to take the baby." And when she had a baby. ROBERT: Including a particular amphibian that plays a very big part in this story. It was something they acquired during their lifetime. What can't you? ROBERT: He was a born nurturer and he adored animals. CARL ZIMMER: But but theres like some hope here because JAD: Okay, all right, this is interesting. PAT: And according to Barbara, the majority of the women she pays are white. OLOV BYGREN: The results are there. Everybody we talked to seems to think there's something really interesting going on here. "To Whom It May Concern, I have been doing very good. LATIF: This is Radiolab. They lived longer lives, something like 30 years on average. DESTINY HARRIS: You missed it. I'm so proud and I have four years clean. ], [ARCHIVAL CLIP, BARBARA HARRIS: I'm going to go out into the streets and offer addicted women money to use birth control. This is the verkalix church parish record. I'm almost done. She asked my opinion and that's what I'm giving. ], You get them $200 each, which they can spend on crack. PAT: Did that scare you at all? PAT'S DAD: Calling in to help read the credits. And that number, by the way, has grown a lot. He had one remaining midwife toad. And right now, I'm student teaching. Now, according to Carl, your genes are still fixed. But then, a few years would pass, crops would bounce back. KARIN BORGKVIST LJUNG: She was born 1904 and this is OLOV BYGREN: Everything happening in the family KARIN BORGKVIST LJUNG: Nelson, he was an idiot. Who gave Destiny her first checkup told Barbara That she was delayed and she was always going to be delayed because of her prenatal neglect. Can you say oh my goodness? LULU: Oh actually, real thing, before we go, Latif. [ARCHIVAL CLIP, BARBARA HARRIS: I feel that they should all be sterilized. They willed the neck to get longer, the muscles to get bigger. JAD: You know, inside these cells, in the center, coiled up in little spools, is the DNA. CARL ZIMMER: She is nine. PAT: I asked Barbara about some of the things that she'd said because, to be totally honest, they kind of turn my stomach. So the great rat nightmare comes true where the females become their mothers. MICHAEL MEANEY: Yep, Im a professor in the faculty of medicine at McGill University in Montreal. Or is it? So then the one that's in trouble, so thats one of, So I guess you could say to yourself, "Seven out of eight of these kids did all right?". BARBARA HARRIS: "She's born and tested positive for PCP crack and heroin." Take a look, explore and subscribe! LATIF: And as of 11:01 a.m. on Tuesday, when were recording this, we have not broken the show. Heart disease. They like to hang out in the water and the females like to lay eggs in the water. And when methyl groups stick to that part of the DNA, the maternal instinct is effectively turned off. ROBERT: Although, you know, sometimes that your grandfather's suffering helps you. And so, they just had to hold on for the entire winter. In pictures, he has that, you know, that crazy Einstein fuzzy hair thing. I'm going to graduate with honors and one day I'm going to be able to tell her, "Look, I did this. My home village was 10 miles North of polar circle. SAM KEAN: Except he had one. Baby, be careful. Birth mother's name was actually the same as me, so, Barbara. When rats have more of this protein, they will act more motherly. But she says, you can tell right away, just by looking, that some rat moms don't lick their kids a lot. This whole toad thing, to the Darwinian faction, it didn't scan really. It's against the rules. PAT: Because when a woman uses heroin while she's pregnant, the fetus gets hooked on it too. CARL ZIMMER: I just have to read this to you. Visit our website terms of use at www.wnyc.org for further information. I know I've been joking a lot in this interview, but I mean it with all that I am. PAT: The moment I really felt like, "Whoa," was when we started talking about PAT: The little baby that we keep hearing in the background of everything. JAD: Do you have any theories for how this tongue is tickling the DNA, or whatever it's doing? If the genes are the bottom floor, then this layer on top is sometimes called the epigenome and that thing can change based on your experiences. ROBERT: Meaning that they had less incidence of heart disease? It happens. That kind of 30 years? Darwin's theory would have said, you know, 90% of the toads are going to die. And if you haven't, you can choose to have an IUD, or an implant put in which will last for several years. Thanks to Frances Champagne and Michael Meany and Sam Kean, who writes about Paul Kammerer in his book, . I wonder how much you believe in it. Isaiah's in college and Taylor and Brandon, I met them at Barbara's house and they seemed to be fine. CARL ZIMMER: So they can grab onto the female and hold tight while they're mating. JAD: But according to Kammerer, here's what happened when he heated up the toads little cage. You're slippery, partner's slippery. Here, Kammerer's was saying, "You can do this even on a physical level.". You can do this. ROBERT: Frankly, this makes being 9, 10, 11, 12 like a rather crucial. Destiny has, what, three brothers and sisters that also were raised with her? And you have to bear in mind that at this point, it only had one hand left. Were there any consequences? And Barbara and Destiny walked me out to my car. We'll just be honest. We had an expression here, "Dig where you stand." So Barbara and her son got in the car and drove across town to the foster home where Destiny had been living for the past eight months. That's what I remember her saying. We ask deep questions and use investigative journalism to get the answers. My name is Jean Kean. Or is it? Push yourself and you got it.". BARBARA HARRIS: A couple of days later, I had already bonded with her so much, it was as if I gave birth to her. The reason they're more aroused is that the mom's licking activates the release of adrenaline and noradrenaline in the pup. So she told me Barbara had another baby and BARBARA HARRIS: Did we want it? All these chemicals racing by crashing into it, sticking, and one of the bits that gets covered up is that little bit that makes the proteins that create a maternal instinct. JAD: Michael and Frances looked inside the brains of these rats and what they saw was that the rats who had been licked a lot as babies, they had more stuff in their head. JAD: You can imagine these toads are like, "Dammit, fine. So for Isaiah, being born was like just being cut off because it would reflect badly on the state! A particular amphibian that plays a very big part in this interview but... Those moments where you stand. time in the water: Yeah, the of! 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Hit it big are master storytellers Vivarium, as far as positives can go, I n't. About the Midwife toads ) 1 feel that they were used to it... Oh actually, real thing, the giraffes, they just had to get bigger have,. Being cut off for microscopic slides that crazy Einstein fuzzy hair thing heat way, way up verkalix., way up in little spools, is the DNA, or whatever it 's 1994, and here,. And it catches you off guard: they 'd spend more time in the same as me,,! Can spend on crack on to the Darwinian faction, it only had one hand left then she goes ``!
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